ADLM (formerly AACC)

Q&A

2022

Women in Laboratory Medicine: A Q&A on Diversity and Inclusion

A Paradigm Shift: Engagement of Clinical Chemistry and Laboratory Medicine Trainees by Innovative Teaching Methods

  • Moderators: Joesph R. Wiencek, Allison B. Chambliss
  • Experts: Roger L. Bertholf, Steven W. Cotten, Christina Ellervik, Justin D. Kreuter, Kamran M. Mirza, Zahra Shajani-Yi
  • DOI: https://doi.org/10.1093/clinchem/hvac036

Interpreting EQA—Understanding Why Commutability of Materials Matters

Pregnancy in the Time of COVID-19: What Are the Challenges for Maternity Care?

Alternative Sample Matrices Supporting Remote Sample Collection during the Pandemic and Beyond

At-Home Testing for Infectious Diseases: The Laboratory Where You Live

2021

Molecular Approaches to Transplant Monitoring; Is the Horizon Here?

Perspectives on Identifying and Treating Familial Hypercholesterolemia in Childhood

  • Moderators: Sarah D. de Ferranti, Dhruv S. Kazi
  • Experts: Kirsten Bibbins-Domingo, Stephen Daniels, Barbara Howaniec, Amit V. Khera, Thomas B. Newman, Louis Vernacchio
  • DOI: https://doi.org/10.1093/clinchem/hvab157

Data Mining Approaches to Reference Interval Studies

Current Utility and Reliability of Biological Variability

Current Testing Strategies for SARS-CoV-2 in the United States

Evolution of Blood Sample Transportation and Monitoring Technologies

  • Moderators: Khushbu Patel, Joe M El-Khoury
  • Experts: Ana-Maria Simundic, Christopher W Farnsworth, Franziska Broell, Jonathan R Genzen, Timothy K Amukele
  • DOI: https://doi.org/10.1093/clinchem/hvab001

Centralized vs Decentralized Molecular Infectious Disease Testing

Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations

Should LC-MS/MS Be the Reference Measurement Procedure to Determine Protein Concentrations in Human Samples?

How Can Routine Clinical Laboratories Keep Up with the Opioid Crisis?

  • Moderator: Christine L H Snozek
  • Experts: Leland B Baskin, Jessica M Boyd, Brian N Kelly, Matthew D Krasowski, S M Hossein Sadrzadeh, Danyel H Tacker
  • DOI: https://doi.org/10.1093/clinchem/hvaa305

The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective

  • Moderator: Linnea M Baudhuin
  • Experts: Julie De Backer, Jodie Ingles, Dianna M Milewicz, Anne Tybjaerg-Hansen
  • DOI: https://doi.org/10.1093/clinchem/hvaa251

2020

Cell-Free DNA Fragmentomics: The New "Omics" on the Block

  • Moderator: Rossa W.K. Chiu
  • Experts: Ellen Heitzer, Y M Dennis Lo, Florent Mouliere, Dana W Y Tsui
  • DOI: https://doi.org/10.1093/clinchem/hvaa258

Examining Laboratory Medicine's Role in Eliminating Health Disparities

  • Moderator: Sarah E. Wheeler
  • Experts: Octavia M Peck Palmer, Dina N Greene, Jason Y Park, Gabrielle Winston-McPherson, Timothy K Amukele, Eliseo J Pérez-Stable
  • DOI: https://doi.org/10.1093/clinchem/hvaa174

Patient-Based Real Time QC

  • Moderator: Tony Badrick
  • Experts: Andreas Bietenbeck, Alex Katayev, Huub H van Rossum, Mark A Cervinski, Tze Ping Loh on behalf of the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Analytical Quality
  • DOI: https://doi.org/10.1093/clinchem/hvaa149

Challenges of High-Resolution Mass Spectrometry For Detecting Designer Drugs

  • Moderator: Frederick G. Strathmann
  • Experts: Kara L. Lynch, Alex Krotulski, Pierre Negri, Julie Cichelli, Markus R. Meyer
  • DOI: https://doi.org/10.1093/clinchem/hvaa118

What is Extrachromosomal Circular DNA and What Does It Do?

  • Moderator: Rossa W.K. Chiu
  • Experts: Anindya Dutta, Anton G. Henssen, Y.M. Dennis Lo, Paul Mischel, Birgitte Regenberg
  • DOI: https://doi.org/10.1093/clinchem/hvaa096

The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception

  • Moderators: Ping Wang, Neil Anderson
  • Experts: Yang Pan, Leo Poon, Carmen Charlton, Nathan Zelyas, David Persing, Daniel Rhoads, Hilary Babcock
  • DOI: https://doi.org/10.1093/clinchem/hvaa080

Fecal Microbiota Transplantations: Where Are We, Where Are We Going, And What is the Role of the Clinical Laboratory?

  • Moderators: Eric M. Ransom, Carey-Ann Burnham
  • Experts: Lee Jones, Colleen S. Kraft, L. Clifford McDonald, Andrew R. Reinink, Vincent B. Young
  • DOI: https://doi.org/10.1093/clinchem/hvaa021

Development, Validation, and Regulatory Considerations for a Liquid Biopsy Test

  • Moderators: Dana W.Y. Tsui, Gideon M. Bluementhal, Reena Philip
  • Experts: J. Carl Barrett, Clara Montagut, Kelli Bramlett, Marc Ladanyi, Soma Ghosh
  • DOI: 10.1373/clinchem.2019.305169

Use of Biomarkers to Detect and Manage Acute Kidney Injury: Has Progress Stalled?

  • Moderator: John C. Lieske
  • Experts: Kianoush Kashani, John Kellum, Jay Koyner, Ravindra Mehta, Chirag R. Parikh
  • DOI: https://doi.org/10.1093/clinchem/hvz026

Predictive and Precision Medicine with Genomic Data

  • Moderator: Linnea M. Baudhuin
  • Experts: Leslie G. Biesecker, Wylie Burke, Eric D. Green, Robert C. Green
  • DOI: 10.1373/clinchem.2019.304345

2019

Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL

  • Moderators: Joe M. El-Khoury, Alan T. Remaley
  • Experts: Børge G. Nordestgaard, Harvey W. Kaufman, Samia Mora, Jing Cao, Jeffrey W. Meeusen
  • DOI: 10.1373/clinchem.2019.307306

Machine Learning for Clinical Chemists

  • Moderator: Tony Badrick
  • Experts: Giuseppe Banfi, Andreas Bietenbeck, Mark A. Cervinski, Tze Ping Loh, Ken Sikaris
  • DOI: 10.1373/clinchem.2019.307512

Challenges Facing Society Journals

  • Moderator: Thomas Annesley
  • Experts: Kent Anderson, Angela Cochran, David Crotty, Richard Gallagher, Lisa Janicke Hinchliffe
  • DOI: 10.1373/clinchem.2019.310268

Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan

  • Moderator: Fred S. Apple
  • Experts: Lori B. Daniels, James Januzzi, Torbjørn Omland, Jordi Ordonez-Llanos, Allan Jaffe
  • DOI: 10.1373/clinchem.2018.28937

Optimal Use of Biomarkers for Chronic Kidney Disease

  • Moderator: W.Greg Miller
  • Experts: Lorin M. Bachmann, Joris R. Delanghe, Lesley A. Inker, Graham R.D. Jones, Joseph A. Vassalotti
  • DOI: 10.1373/clinchem.2018.299073

Biobanking for Metabolomics and Lipidomics in Precision Medicine

  • Moderator: Jennifer A. Kirwan
  • Experts: Rima Kaddurah-Daouk, Todd Mitchell, Tobias Pischon, Michael A. Schmidt, Vidya Velagapudi
  • DOI: 10.1373/clinchem.2018.298620

What the Protecting Access to Medicare Act Means for Clinical Laboratories

  • Moderators: James H. Nichols, Vincent G. Stine
  • Experts: Rodney W. Forsman, Lee H. Hilborne, Elissa B. Passiment, Paul Radensky, Charles B. Root, Ester Stein
  • DOI: 10.1373/clinchem.2019.303255

Privacy in Direct-to-Consumer Genetic Testing

  • Moderator: Jason Y. Park
  • Experts: Michael T. Risher, Timothy Caulfield, Linnea M. Baudhuin, Abraham P. Schwab
  • DOI: 10.1373/clinchem.2018.298935

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

  • Moderators: Felix Leung, Livia S. Eberlin
  • Experts: Kristina Schwamborn, Ron M.A. Heeren, Nicholas Winograd, R. Graham Cooks
  • DOI: 10.1373/clinchem.2018.289694

Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome

  • Moderator: Joseph R. Wiencek
  • Experts: Christopher R. McCartney, Alice Y. Chang, Joely A. Straseski, Richard J. Auchus, Alison Woodworth
  • DOI: 10.1373/clinchem.2017.284331

Maintaining Research and Publication Integrity

  • Moderators: Nader Rifai, Thomas M. Annesley
  • Experts: Scott Moore, Arthur L. Caplan, Deborah J. Sweet, Peter Hornung, Frits R. Rosendaal
  • DOI: 10.1373/clinchem.2018.298901

The Microbiome and Men's Health

  • Moderator: Elizabeth A. Platz
  • Experts: Cindy M. Liu, Dominique S. Michaud, Noel T. Mueller, Jacques Ravel
  • DOI: 10.1373/clinchem.2018.287284

2018

Updates on Screening, Prevention, Treatment, and Genetic Markers for Preeclampsia

  • Moderator: Glenn E. Palomaki
  • Experts: James N. Martin, S. Ananth Karumanchi, Liona C. Poon
  • DOI: 10.1373/clinchem.2018.289801

Influence of Molecular Testing on Influenza Diagnosis

  • Moderators: Melanie L. Yarbrough, Carey-Ann D. Burnham
  • Experts: Neil W. Anderson, Ritu Banerjee, Christine C. Ginocchio, Kimberly E. Hanson, Timothy M. Uyeki
  • DOI: 10.1373/clinchem.2018.289363

Learning in the 21st Century: Concepts and Tools

  • Moderator: Nader Rifai
  • Experts: Todd Rose, Graham T. McMahon, Bror Saxberg, Ulrik Juul Christensen
  • DOI: 10.1373/clinchem.2018.292383

The Power of Social Media in Medicine and Medical Education: Opportunities, Risks, and Rewards

  • Moderator: Amy K. Saenger
  • Experts: Michael Berkwits, Simon Carley, Shannon Haymond, Marie Ennis-O'Connor, Jonathan Sherbino, Stephen W. Smith
  • DOI: 10.1373/clinchem.2018.288225

There's No Place Like Home: Exploring Home-Based, Acute-Level Healthcare

  • Moderators: Michelle L. Parker, Paul M. Yip
  • Experts: Linda V. DeCherrie, Christian Escobar, Anna K. Fuezery, Christopher P. Price, Andrew St. John
  • DOI: 10.1373/clinchem.2017.283093

What's New in Laboratory Test Utilization Management?

  • Moderator: Geoffrey S. Baird
  • Experts: Brian R. Jackson, Jane Dickerson, Ken Sikaris, Bernard Croal, Michael Laposata
  • DOI: 10.1373/clinchem.2017.280214

Current and Emerging Multianalyte Assays with Algorithmic Analyses—Are Laboratories Ready for Clinical Adoption?

  • Moderators: Jessica M. Colón-Franco, Patrick M.M. Bossuyt
  • Experts: Alicia Algeciras-Schimnich, Christopher Bird, Julia Engstrom-Melnyk, Martin Fleisher, Michael Kattan, Geralyn Lambert-Messerlian
  • DOI: 10.1373/clinchem.2017.275677

Debates in Pain Management Testing

  • Moderator: Stacy E.F. Melanson
  • Experts: William A. Clarke, Keith Fragoza, Christopher Gilligan, Rebecca Holdren, Paul J. Jannetto, Barbarajean Magnani, Christine Moore
  • DOI: 10.1373/clinchem.2017.275693

A Q&A with the Qualcomm Tricorder XPRIZE Winners

  • Moderators: Ann M. Gronowski, Shannon Haymond
  • Experts: Basil Harris, Chung Kang Peng, Sandeep (Sonny) S. Kohli
  • DOI: 10.1373/clinchem.2017.278853

Gestational Diabetes Mellitus: Why the Controversy?

  • Moderator: David B. Sacks
  • Experts: Donald R. Coustan, Tim Cundy, Lois Donovan, Moshe Hod
  • DOI: 10.1373/clinchem.2016.266577

Challenges and Opportunities in Implementing Total Laboratory Automation

  • Moderator: Jonathan R. Genzen
  • Experts: Carey-Ann D. Burnham, Robin A. Felder, Charles D. Hawker, Giuseppe Lippi, Octavia M. Peck Palmer
  • DOI: 10.1373/clinchem.2017.274068

Dietary Fat: Friend or Foe?

  • Moderators: Cara B. Ebbeling, Ian S. Young
  • Experts: Alice H. Lichtenstein, David S. Ludwig, Michelle McKinley, Rafael Perez-Escamilla, Eric Rimm
  • DOI: 10.1373/clinchem.2017.274084

2017

New Therapies for Treating Hepatitis C Virus: Impact on Laboratory Testing Recommendations and Clinical Management

  • Moderators: Nicole V. Tolan, Gary L. Horowitz
  • Experts: Joel Dore, Francisco Guarner, Ruth Ann Luna, Yehuda Ringel
  • DOI: 10.1373/clinchem.2016.266569

Microbiome-Based Diagnostics: Ready for Applications in Laboratory Medicine?

  • Moderator: James Versalovic
  • Experts: Camilla S. Graham, David Hillyard, William Osburn, Stuart Ray
  • DOI: 10.1373/clinchem.2016.264473

Impact of Novel Psychoactive Substances on Clinical and Forensic Toxicology and Global Public Health

  • Moderator: Marilyn A. Huestis
  • Simon D. Brandt, Suman Rana, Volker Auwärter, Michael H. Baumann
  • DOI: 10.1373/clinchem.2017.274662

The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges

  • Moderators: Angela W.S. Fung, Daniel Beriault, Eleftherios P. Diamandis
  • Experts: Carey-Ann D. Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J. Langford
  • DOI: 10.1373/clinchem.2017.272294

Patient Privacy and Clinical Laboratory Data 

  • Moderator: Jason Y. Park
  • Experts: Toby C. Cornish, Michael Hogarth, Brian R. Jackson, Kristen B. Rosati
  • DOI: 10.1373/clinchem.2016.266551

The Phoenix Rises: The Rebirth of Cancer Immunotherapy

  • Moderators: Ivan M. Blasutig, Sofia Farkona
  • Experts: Elizabeth I. Buchbinder, Jason J. Luke, Padmanee Sharma, Mario Sznol
  • DOI: 10.1373/clinchem.2016.267849

Wellness Initiatives: Benefits and Limitations

  • Moderators: Michelle Li, Eleftherios P. Diamandis
  • Experts: Nigel Paneth, Kiang-Teck J. Yeo, Henrik Vogt, Stephen R. Master
  • DOI: 10.1373/clinchem.2017.273672

Emerging Considerations for Noninvasive Prenatal Testing

  • Moderators: Nichole Korpi-Steiner, Rossa W.K. Chiu
  • Experts: Subhashini Chandrasekharan, Lyn S. Chitty, Mark I. Evans, Judith A. Jackson, Glenn E. Palomaki
  • DOI: 10.1373/clinchem.2016.266544

Are We There Yet? Laboratory Preparedness for Emerging Infectious Diseases

  • Moderators: Carey-Ann D. Burnham, Jennie H. Kwon
  • Experts: Eileen M. Burd, Sheldon Campbell, Peter C. Iwen, Melissa B. Miller
  • DOI: 10.1373/clinchem.2016.265850

Direct-to-Consumer Testing

  • Moderators: Michelle Li, Eleftherios P. Diamandis
  • Experts: David Grenache, Michael J. Joyner, Daniel T. Holmes, Rodger Seccombe
  • DOI: 10.1373/clinchem.2016.260349

Biomedical Journals and Preprint Services: Friends or Foes?

  • Moderators: Thomas Annesley, Mitchell Scott
  • Experts: Hilda Bastian, Vivian Fonseca, John P.A. Ioannidis, Michael A. Keller, Jessica Polka
  • DOI: 10.1373/clinchem.2016.268227

Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury

  • Moderator: Fred S. Apple
  • Experts: Allan S. Jaffe, Scott Sharkey, Peter Kavsak, Michael C. Kontos, Amy K. Saenger, Stephen Smith
  • DOI: 10.1373/clinchem.2016.257428

2016

The Use of Targeted Therapies for Precision Medicine in Oncology

  • Moderators: Nicole White-Al Habeeb, Vathany Kulasingam, and Eleftherios P. Diamandis
  • Experts: George M. Yousef, Gregory J. Tsongalis, Louis Vermeulen, Ziqiang Zhu, and Suzanne Kamel-Reid
  • DOI: 10.1373/clinchem.2015.247882

Newborn Screening for Lysosomal Storage Disorders: Quo Vadis?

  • Moderators: Roy W.A. Peake and Deborah L. Marsden
  • Experts: Olaf A. Bodamer, Michael H. Gelb, David S. Millington and Frits Wijburg
  • DOI: 10.1373/clinchem.2016.258459

CRISPR-Cas9 System: Opportunities and Concerns

  • Moderators: Stella Vasiliou and Eleftherios P Diamandis
  • Experts: George Church, Henry T Greely, Françoise Baylis, Charis Thompson, and Gerold Schmitt‐Ulms
  • DOI: 10.1373/clinchem.2016.263186

Zika Virus: From Obscurity to Potentially Devastating International Threat

  • Moderators: Marie Louise Landry
  • Experts: Albert I. Ko, Laura D. Kramer and Nikolaos Vasilakis
  • DOI: 10.1373/clinchem.2016.261917

Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

  • Moderators: Felix Leung, Vathany Kulasingam, and Eleftherios P. Diamandis
  • Experts: Dave S. B. Hoon, Kenneth Kinzler, Klaus Pantel, and Catherine Alix- Panabières
  • DOI: 10.1373/clinchem.2016.260331

Reference Intervals: Strengths, Weaknesses, and Challenges

  • Moderators: W. Greg Miller and Gary L. Horowitz
  • Experts: Ferruccio Ceriotti, James K. Fleming, Neil Greenberg, Alexander Katayev, Graham R.D. Jones, William Rosner, and Ian S. Young
  • DOI: 10.1373/clinchem.2016.256511

Classifying Germline Sequence Variants in the Era of Next-Generation Sequencing

  • Moderators: Linnea M. Baudhuin and Birgit H. Funke
  • Experts: Lora H. Bean, Joshua L. Deignan, Sean Hofherr, David T. Miller, Narasimhan Nagan, Avni Santani, and Carol Saunders
  • DOI: 10.1373/clinchem.2015.247874

Pharmacists in the Laboratory Space: Friends or Foes?

  • Moderator: Ann M. Gronowski
  • Experts: Alex Adams, Christopher Ball, Charlotte A. Gaydos, and Michael Klepser
  • DOI: 10.1373/clinchem.2015.247445

Proteogenomics: Opportunities and Caveats

  • Moderators: Lampros Dimitrakopoulos, Ioannis Prassas, and Eleftherios P. Diamandis
  • Experts: Alexey Nesvizhskii, Thomas Kislinger, Jacob Jaffe, and Andrei Drabovich
  • DOI: 10.1373/clinchem.2015.247858

Nonfasting Sample for the Determination of Routine Lipid Profile: Is It an Idea Whose Time Has Come?

  • Moderators: Nader Rifai and Ian S. Young
  • Experts: Børge G. Nordestgaard, Anthony S. Wierzbicki, Hubert Vesper, Samia Mora, Neil J. Stone, Jacques Genest, and Greg Miller
  • DOI: 10.1373/clinchem.2015.247866

Clostridium difficile—Diagnostic and Clinical Challenges

  • Moderator: Carey-Ann D. Burnham
  • Experts: Erik R. Dubberke, Larry K. Kociolek, Christopher R. Polage, and Thomas V. Riley
  • DOI: 10.1373/clinchem.2015.243717

A Spectrum of Views on Clinical Mass Spectrometry

  • Moderators: Thomas Annesley and Eleftherios Diamandis
  • Experts: Lorin Bachmann, Samir Hanash, Bradley Hart, Reza Javahery, Ravinder Singh, and Richard Smith
  • DOI: 10.1373/clinchem.2015.250258

2015

Vitamin D: The More We Know, the Less We Know

  • Moderators: Mitchell G. Scott and Ann M. Gronowski
  • Experts: Ian R. Reid, Michael F. Holick, Ravi Thadhani, and Karen Phinney
  • DOI: 10.1373/clinchem.2014.222521

Biomarkers in the Pharmaceutical Industry

  • Moderator: Omar F. Laterza
  • Experts: Andrew Plump, Jeffrey E. Ming, Susan Richards, Michael E. (Ransom) Burczynski, John A. Wagner, and Scott D. Patterson
  • DOI: 10.1373/clinchem.2014.225284

"Big Data" in Laboratory Medicine

  • Moderators: Nicole V. Tolan and M. Laura Parnas
  • Experts: Linnea M. Baudhuin, Mark A. Cervinski, Albert S. Chan, Daniel T. Holmes, Gary Horowitz, Eric W. Klee, Rajiv B. Kumar, and Stephen R. Master
  • DOI: 10.1373/clinchem.2015.248591

Triangulating Dynamic of Clinical Laboratory Testing

  • Moderators: Kerri Weinert, Peter Gyorda, and Nader Rifai
  • Experts: Susan Evans, Harvey W. Kaufman, Charles S. Eby, Edward R. Ashwood, and Norman Moore
  • DOI: 10.1373/clinchem.2015.248112

Clopidogrel and CYP2C19: PharmacogeneticTesting Ready for Clinical Prime Time?

  • Moderators: Michael J. Knauer and Eleftherios P. Diamandis
  • Experts: Jean-Sebastien Hulot, Richard B. Kim, and Derek Y.F. So
  • DOI: 10.1373/clinchem.2015.238105

Disruptive Innovation in Laboratory Medicine

  • Moderator: Nader Rifai
  • Experts: Eric Topol, Eugene Chan, Y.M. Dennis Lo, and Carl T. Wittwer
  • DOI: 10.1373/clinchem.2015.243667

A Renin-ssance in Primary Aldosteronism Testing: Obstacles and Opportunities for Screening, Diagnosis, and Management

  • Moderators: Joshua E. Raizman and Eleftherios P. Diamandis
  • Experts: Daniel Holmes, Michael Stowasser, Richard Auchus, and Etienne Cavalier
  • DOI: 10.1373/clinchem.2015.242990

Biomarkers, Assays, and Therapies for Alzheimer Disease

  • Moderators: Daniel R. Beriault and Eleftherios P. Diamandis
  • Experts: Erik Portelius, Armand Perret-Liaudet, and Stephen Salloway
  • DOI: 10.1373/clinchem.2015.241901

Preanalytical Considerations in the Design of Clinical Trials and Epidemiological Studies

  • Moderator: Mark D. Kellogg
  • Experts: Christina Ellervik, David Morrow, Ann Hsing, Evan Stein, and Amar A. Sethi
  • DOI: 10.1373/clinchem.2014.226118

Preeclampsia: An Old Disease with New Tools for Better Diagnosis and Risk Management

  • Moderators: Mohamed Abou El Hassan and Eleftherios P. Diamandis
  • Experts: S. Ananth Karumanchi, Andrew H. Shennan, and Robert N. Taylor
  • DOI: 10.1373/clinchem.2014.230565

The Changing Face of Laboratory Medicine: A More Service and Less Academically Oriented Profession?

  • Moderators: Mitchell G. Scott and Nader Rifai
  • Experts: Brian Smith, Michael Oellerich, Mauro Panteghini, Fred Apple, Ken Sikaris, and Ian Young
  • DOI: 10.1373/clinchem.2014.230300

Next Generation Sequencing in Clinical Diagnostics: Experiences of Early Adopters

  • Moderator: Elaine Lyon, Franklin R. Cockerill III
  • Richard Press, and Glenn E. Palomaki
  • DOI: 10.1373/clinchem.2014.222687

2014

Animal Olfactory Detection of Disease: Promises and Pitfalls

  • Moderators: Tracy Teodoro-Morrison, Eleftherios P. Diamandis, and Nader Rifai
  • Experts: Bart Jan Christiane Weetjens, Giorgio Pennazza, Nanne K. de Boer, and Marije K. Bomers
  • DOI: 10.1373/clinchem.2014.231282

Critical Issues in International Biobanking

  • Moderator: Jim Vaught
  • Experts: Akin Abayomi, Tim Peakman, Peter Watson, Lise Matzke, and Helen Moore
  • DOI: 10.1373/clinchem.2014.224469

What Is Wrong with Clinical Proteomics?

  • Moderators: Ashley Di Meo and Eleftherios P. Diamandis
  • Experts: Henry Rodriguez, Andrew N. Hoofnagle, John Ioannidis, and Mary Lopez
  • DOI: 10.1373/clinchem.2014.225185

Registering Diagnostic and Prognostic Trials of Tests: Is It the Right Thing to Do?

  • Moderators: Nader Rifai and Patrick M.M. Bossuyt
  • Experts: John P.A. Ioannidis, Kurtis R. Bray, Lisa M. McShane, Robert M. Golub, and Lotty Hooft
  • DOI: 10.1373/clinchem.2014.226100

Natriuretic Peptides in Heart Failure

  • Moderators: Danny C.C. Lin and Eleftherios P. Diamandis
  • Experts: James L. Januzzi Jr., Alan Maisel, Allan S. Jaffe, and Aldo Clerico
  • DOI: 10.1373/clinchem.2014.223057

Harmonization of Test Results: What Are the Challenges; How Can We Make It Better?

  • Moderator: W. Greg Miller
  • Experts: John H. Eckfeldt, Joseph Passarelli, William Rosner, and Ian S. Young
  • DOI: 10.1373/clinchem.2012.201186

Novel Biomarkers for Acute Myocardial Infarction: Is MicroRNA the New Kid on the Block?

  • Moderators: Joshua E. Raizman and Eleftherios P. Diamandis
  • Experts: Katey Rayner, Stephanie Dimmeler, George A. Calin, and Thomas Thum
  • DOI: 10.1373/clinchem.2013.215491

Interferon γ–Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons

  • Moderators: Nira R. Pollock and Alexander J. McAdam
  • Experts: Madhukar Pai, Edward A. Nardell, John Bernardo, Niaz Banaei, and Jay Mobo
  • DOI: 10.1373/clinchem.2012.201178

Helicobacter pylori Diagnostics and Treatment: Could a Lack of Universal Consensus Be the Best Consensus?

  • Moderator: Marc R. Couturier
  • Experts: Barry J. Marshall, Karen J. Goodman, and Francis Mégraud
  • DOI: 10.1373/clinchem.2012.201475

Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now?

  • Moderator: Brad S. Karon
  • Experts: Gilles Montalescot, Neil S. Harris, Søren Risom Kristensen, and Matthew Price
  • DOI: 10.1373/clinchem.2013.208942

Biomarkers for Acute Kidney Injury: Where Are We Today? Where Should We Go?

  • Moderator: John C. Lieske
  • Experts: Lakhmir Chawla, Kianoush Kashani, John A. Kellum, Jr., Jay L. Koyner, and Ravindra L. Mehta
  • DOI: 10.1373/clinchem.2012.201988

The Ethical Implications of Preimplantation Genetic Diagnosis

  • Moderator: Ann M. Gronowski
  • Experts: Richard T. Scott, Jr., Arthur L. Caplan, and Lawrence J. Nelson
  • DOI: 10.1373/clinchem.2013.202515

2013

Automation in the Clinical Microbiology Laboratory

  • Moderator: Carey-Ann D. Burnham
  • Experts: W. Michael Dunne, Jr., Gilbert Greub, Susan M. Novak, and Robin Patel
  • DOI: 10.1373/clinchem.2012.201038

Identifying Antibiotic-Resistant Bacteria in Hospitalized Patients: What Is the Role of Active-Surveillance Cultures?

  • Moderator: Thomas J. Sandora
  • Experts: Susan A. Dolan, Stephan Harbarth, Susan S. Huang, Alexander J. McAdam, and Aaron M. Milstone
  • DOI: 10.1373/clinchem.2012.201046

Use of MALDI-TOF for Diagnosis of Microbial Infections

  • Moderators: Dana Bailey and Eleftherios P. Diamandis
  • Experts: Gilbert Greub, Susan M. Poutanen, Jens Jørgen Christensen, and Markus Kostrzew
  • DOI: 10.1373/clinchem.2013.204644

Bioinformatics: What the Clinical Laboratorian Needs to Know and Prepare For

  • Moderator: Gregory J. Tsongalis
  • Experts: Elizabeth Chao, Jill M. Hagenkord, Tina Hambuch, and Jason H. Moore
  • DOI: 10.1373/clinchem.2012.198226

A New Era in Prenatal Diagnosis: The Use of Cell-Free Fetal DNA in Maternal Circulation for Detection of Chromosomal Aneuploidies

  • Moderators: Jennifer L. Shea and Eleftherios P. Diamandis
  • Experts: Barry Hoffman, Y.M. Dennis Lo, Jacob Canick, and Dirk van den Boom
  • DOI: 10.1373/clinchem.2012.201996

FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?

  • Moderator: Mitchell G. Scott
  • Experts: Edward R. Ashwood, Thomas M. Annesley, Debra G.B. Leonard, and Michael C. Burgess
  • DOI: 10.1373/clinchem.2013.204958

Cobalt and Chromium Measurement in Patients with Metal Hip Prostheses

  • Moderators: Mathew P. Estey and Eleftherios P. Diamandis
  • Experts: Catherine Van Der Straeten, Stephen S. Tower, Alister J. Hart, and Thomas P. Moyer
  • DOI: 10.1373/clinchem.2012.193037

Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics?

  • Moderator: Carlo Brugnara
  • Experts: John Adamson, Michael Auerbach, Robert Kane, Iain Macdougall, and Alan Mast
  • DOI: 10.1373/clinchem.2012.182071

Communication of Scientific Information: Is It Time to Reassess?

  • Moderators: Nader Rifai and John Sack
  • Experts: Michael A. Keller, Anurag Acharya, Philip E. Bourne, Mike Rossner, and Stewart Wills
  • DOI: 10.1373/clinchem.2012.194738

Pheochromocytoma

  • Moderators: Mathew P. Estey and Eleftherios P. Diamandis
  • Experts: Graeme Eisenhofer, Karel Pacak, Eamonn R. Maher, William F. Young, and Ronald R. de Krijger
  • DOI: 10.1373/clinchem.2012.182246

MicroRNA Analysis: Is It Ready for Prime Time?

  • Moderator: Gregory J. Tsongalis
  • Experts: George Calin, Pierre Cordelier, Carlo Croce, Federico Monzon, and Anna E. Szafranska-Schwarzbach
  • DOI: 10.1373/clinchem.2012.185009

Pancreatic Cancer

  • Moderators: Caitlin C. Chrystoja and Eleftherios P. Diamandis
  • Experts: Randall Brand, Felix Rückert, Randy Haun, and Rafael Molina
  • DOI: 10.1373/clinchem.2012.196642

2012

NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: Can We Clarify the Controversy about Cholesterol Screening and Treatment in Childhood?

  • Moderator: Sarah D. de Ferranti
  • Experts: Stephen R. Daniels, Matthew Gillman, Louis Vernacchio, Jorge Plutzky, and Annette L. Baker
  • DOI: 10.1373/clinchem.2012.182089

Autoimmune Diseases: Early Diagnosis and New Treatment Strategies

  • Moderators: Danijela Konforte and Eleftherios P. Diamandis
  • Experts: Walther J. van Venrooij, Rik Lories, and Michael M. Ward
  • DOI: 10.1373/clinchem.2012.189480

Thyroid Function during Pregnancy: Who and How Should We Screen?

  • Moderator: Ann M. Gronowski
  • Experts: James Haddow, Sarah Kilpatrick, John H. Lazarus, and Roberto Negro
  • DOI: 10.1373/clinchem.2012.185017

Ectopic Pregnancy

  • Moderators: Julie L.V. Shaw and Eleftherios P. Diamandis
  • Experts: Andrew Horne, Kurt Barnhart, Tom Bourne, and Ioannis E. Messinis
  • DOI: 10.1373/clinchem.2012.184168

Antibiotic Resistance: How Serious Is the Problem, and What Can Be Done?

  • Moderators: Alexander J. McAdam
  • Experts: David C. Hooper, Alfred DeMaria, Brandi M. Limbago, Thomas F. O'Brien, and Betsy McCaughey
  • DOI: 10.1373/clinchem.2011.181636

Altering the Landscape for Women in Clinical Chemistry: Perspectives from Multigenerational Leaders

  • Moderators: Shannon Haymond and Amy K. Saenger
  • Experts: Helen M. Free, Jocelyn M. Hicks, Marilyn A. Huestis, Rita Horvath, and Corinne R. Fantz
  • DOI: 10.1373/clinchem.2011.174284

The Obesity Epidemic

  • Moderators: Jennifer Shea and Eleftherios P. Diamandis
  • Experts: Arya M. Sharma, Jean-Pierre Després, Shereen Ezzat, and Frank Greenway
  • DOI: 10.1373/clinchem.2011.180976

Liquid Chromatography-Tandem Mass Spectrometry or Automated Immunoassays: What Are the Future Trends in Therapeutic Drug Monitoring?

  • Moderators: Gunnar Brandhorst and Michael Oellerich
  • Experts: Gregory Maine, Paul Taylor, Gerhard Veen, and Pierre Wallemacq
  • DOI: 10.1373/clinchem.2011.167189

Is Leadership a Noun or Verb?

  • Moderator: Thomas M. Annesley
  • Experts: James S. Hernandez, Angie Morgan, Ora Pescovitz, and Ian Wright
  • DOI: 10.1373/clinchem.2011.165639

How Well Are We Training the Next Generation of Clinical Pathologists and Clinical Laboratory Directors? A Global Perspective

  • Moderator: Mitchell G. Scott
  • Experts: Brian R. Smith, Alan H.B. Wu, Ian S. Young, Mario Plebani, and Rossa W.K. Chiu
  • DOI: 10.1373/clinchem.2011.171199

Newborn Screening for Metabolic Disorders: How Are We Doing, and Where Are We Going?

  • Moderator: Michael J. Bennett
  • Experts: Piero Rinaldo, Bridget Wilcken, Kenneth A. Pass, Michael S. Watson, and Ronald J.A. Wanders
  • DOI: 10.1373/clinchem.2011.171215

The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers

  • Moderators: Fred S. Apple and David Morrow
  • Experts: Christian Zaugg, David Hickey, Michelle Zaharik, John J. Blackwood, and Kirsten Jakobsen
  • DOI: 10.1373/clinchem.2011.165860

2011

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

  • Moderator: Andrew Hoofnagle
  • Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
  • DOI: 10.1373/clinchem.2010.158311

Invest or Not to Invest ... Not Always an Easy Question to Answer

  • Moderator: Susan Evans
  • Experts: Emery Stephans, Avi Kulkarni, Aaron Geist and Quintin Lai
  • DOI: 10.1373/clinchem.2010.152132

Direct-to-Consumer Genetic Testing: Reliable or Risky?

  • Moderators: David H. Spencer and Christina Lockwood
  • Experts: Eric Topol, James P. Evans, Robert C. Green, Elizabeth Mansfield, and Zivana Tezak
  • DOI: 10.1373/clinchem.2011.167197

Circulating Cancer Cells and Their Clinical Applications

  • Moderator: Eleftherios P. Diamandis
  • Experts: Klaus Pantel, Howard I. Scher, Leon Terstappen, and Evi Lianidou
  • DOI: 10.1373/clinchem.2011.166678

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

  • Moderator: Andrew N. Hoofnagle
  • Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
  • DOI: 10.1373/clinchem.2010.158311

Clinical Applications for Vitamin D Assays: What Is Known and What Is Wished for

  • Moderator: Michael Kleerekoper
  • Experts: Rosemary L. Schleicher, John Eisman, Roger Bouillon, Ravinder J. Singh and Michael F. Holick
  • DOI: 10.1373/clinchem.2010.154997

Oral Fluid Testing: Promises and Pitfalls

  • Moderator: Marilyn A. Huestis
  • Experts: Alain Verstraete, Tai C. Kwong, Jorg Morland, Michael J. Vincent, and Raphael de la Torre
  • DOI: 10.1373/clinchem.2010.152124

Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy

  • Moderators: Maria Diamandis Pasic and Eleftherios P. Diamandis
  • Experts: JoAnne McLaurin, David M. Holtzman, Gerold Schmitt-Ulms, and Rémi Quirion
  • DOI: 10.1373/clinchem.2011.161828

Individually Tailored Immunosuppression: Is There a Role for Biomarkers?

  • Moderators: Gunnar Brandhorst and Michael Oellerich
  • Experts: ;Mercè Brunet, Richard Kowalski, Alexander Vinks and Pierre Wallemacq
  • DOI: 10.1373/clinchem.2010.159871

The Quest for Clean Competition in Sports: Are the Testers Catching the Dopers?

  • Moderator: Anthony W. Butch
  • Experts: John A. Lombardo, Larry D. Bowers, Julie Chu and David A. Cowan
  • DOI: 10.1373/clinchem.2010.155002

The Use of Human Tissues in Research: What Do We Owe the Research Subjects?

  • Moderator: Ann M. Gronowski
  • Experts: Jack Moye, Jr., David S. Wendler, Arthur L. Caplan and Michael Christman
  • DOI: 10.1373/clinchem.2010.154989

2010

Cancer Genomes

  • Moderator: Eleftherios P. Diamandis
  • Experts: Thomas Hudson, Olli Kallioniemi, Edison T. Liu and Carlos López-Otín
  • DOI: 10.1373/clinchem.2010.152140

Nanotechnology: Improving Clinical Testing?

  • Moderators: Paolo Fortina and Larry J. Kricka
  • Experts: Dawn Bonnell, Amit Kulkarni, Joseph Wang, Yuri Miyahara, and David Ure
  • DOI: 10.1373/clinchem.2009.138750

Epigenomics-Based Diagnostics

  • Moderator: Eleftherios P. Diamandis
  • Experts: David Sidransky, Peter W. Laird, Paul Cairns and Bharati Bapat
  • DOI: 10.1373/clinchem.2010.148007

Direct-to-Consumer Genotyping: Are We Ready for a Brave New World?

  • Moderators: Mark A. Cervinski and Gregory J. Tsongalis
  • Experts: Lew Bender, Lawrence M. Silverman, Mary Bet Dinulos, Jim Nickel and Wayne Grody
  • DOI: 10.1373/clinchem.2009.138743

High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?

  • Moderator: Fred S. Apple
  • Experts: Alan Wu, Paul Collinson, Allan Jaffe and David Morrow
  • DOI: 10.1373/clinchem.2009.138727

KRAS Mutation Detection: A New Look at an Old Gene

  • Moderators: Joel A. Lefferts and Gregory J. Tsongalis
  • Experts:  Arief A. Suriawinata, William K. Funkhouser, Marc Ladanyi, Jan A. Nowak and J. Marc Pipas
  • DOI: 10.1373/clinchem.2009.138735

Microtechnology in the Clinical Laboratory: Will It Solve Analytical Problems, and When Will It Make an Impact?

  • Moderator: Peter Wilding
  • Experts: Sabeth Verpoorte, M. Allen Northrup, Paul Yager, Stephen Quake and James Landers
  • DOI: 10.1373/clinchem.2009.138719

Prostate Cancer Screening with Prostate-Specific Antigen Testing: More Answers or More Confusion?

  • Moderator: Eleftherios P. Diamandis
  • Experts:  Patrick Walsh, Klaus Jung, William Catalona and Neil Fleshner
  • DOI: 10.1373/clinchem.2009.140046

Detection of Biological Agents Used for Terrorism: Are We Ready?

  • Moderator: Mark Kellogg
  • Experts: Mark Hollis, Cheryl Gauthier, and Tom O'Brien
  • DOI: 10.1373/clinchem.2009.139493

2009

Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?

  • Moderator: Eleftherios P. Diamandis
  • Experts: Karl V. Voelkerding, Rade Drmanac, David Agus, and John McPherson
  • DOI: 10.1373/clinchem.2009.133389

Clinical Assays for Human Chorionic Gonadotropin: What Should We Measure and How?

  • Moderator: Ann M. Gronowski
  • Experts: Catherine Sturgeon, Ulf-Håkan Stenman, Glenn D. Braunstein, Anthony W. Butch and David A. Cowan
  • DOI: 10.1373/clinchem.2009.133595

Tight Glucose Control in Critically Ill Patients: Should Glucose Meters Be Used?

  • Moderator: David B. Sacks
  • Experts: Greet Van den Berghe, Sue Kirkman, Gerald Kost, Ron Ng and Sverre Sandberg
  • DOI: 10.1373/clinchem.2009.131318

Protein Quantification by Mass Spectrometry: Is It Ready for Prime Time?

  • Moderator: Eleftherios P. Diamandis
  • Experts: Samir Hanash, Mary Lopez, Steven Carr, and Emanuel F. Petricoin III
  • DOI: 10.1373/clinchem.2009.128058 

Mass Spectrometry in the Clinical Laboratory: How Have We Done, and Where Do We Need to Be?

  • Moderator: Thomas Annesley
  • Experts: Joseph Majzoub, Ann Hsing, Alan Wu, Alan Rockwood and Donald Mason
  • DOI: 10.1373/clinchem.2009.127522