Association for Diagnostics & Laboratory Medicine // Science & Research // Clinical Chemistry Journal // Q&A

Q&A

2024

More Than a Decade of Rapid Genomic Sequencing: Where Are We Now?

Moderator: Carol J. Saunders
Experts: Luca Brunelli, Michael J. Deem, Emily G. Farrow, Madhuri Hegde, Zornitza Stark
DOI: https://doi.org/10.1093/clinchem/hvae025

Clinical Decision Support in Laboratory Medicine

Moderator: Kay Weng Choy
Experts: Pieter Cornu, Anand S. Dighe, Andrew Georgiou, Lindsay Peters, Kenneth A. Sikaris, Tze Ping Loh
DOI: https://doi.org/10.1093/clinchem/hvae002

New Sepsis Diagnostics and Their Impacts on Clinical Decision-Making and Treatment Protocols

Moderator: Allison B. Chambliss
Experts: Sridevi Devaraj, Jeremiah S. Hinson, Sophie E. Katz, Russell B. Kerbel, Nathan A. Ledeboer
DOI: https://doi.org/10.1093/clinchem/hvad211

Looking to the Future of Early Detection in Cancer: Liquid Biopsies, Imaging, and Artificial Intelligence

Moderator: Stefan Foser
Experts: Kenneth Maiese, Subba R. Digumarthy, Joan Anton Puig-Butille, Christian Rebhan
DOI: https://doi.org/10.1093/clinchem/hvad196

2023

Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age

Moderators: Anna E. Merrill, Thomas J.S. Durant
Experts: Jason Baron, J. Stacey Klutts, Amrom E. Obstfeld, David Peaper, Michelle Stoffel, Sarah Wheeler, Mark A. Zaydman
DOI: https://doi.org/10.1093/clinchem/hvad183

Sustainability in Laboratory Medicine

Moderator: Raeshun T. Glover
Experts: James Connelly, Alistair Gammie, Jane Kilcoyne, Tomris Ozben, Alicja Santos, Joesph R. Wiencek
DOI: https://doi.org/10.1093/clinchem/hvad156

Generative Artificial Intelligence: More of the Same or Off the Control Chart?

Moderators: Christopher Snyder, Mark A. Zaydman
Experts: Thomas Chong, Jason Baron, Jonathan H. Chen, Brian Jackson
DOI: https://doi.org/10.1093/clinchem/hvad129

In-Hospital Manufacturing of Cellular Therapies Using Automated Systems

Moderator: Stephan Kadauke
Experts: Martín H. Bonamino, Bruce L. Levine, Richard Harrison, Ohad Karnieli
DOI: https://doi.org/10.1093/clinchem/hvad102

International Perspectives on GFR Estimation and Race-Based Adjustments

Moderators: Joe M. El-Khoury, Amy B. Karger
Experts: Etienne Cavalier, Robert Kalyesubula, Boon Wee Teo, Verônica T. Costa e Silva, Lesley A. Inker
DOI: https://doi.org/10.1093/clinchem/hvad095

Tissue Mass Spectrometry: How Solid Is Our Future?

Moderators: Daisy Unsihuay, William S. Phipps
Experts: Amanda G. Paulovich, Jessica R. Chapman, Axel Ducret, Livia S. Eberlin, Jeffrey M. Spraggins, Richard J.A. Goodwin
DOI: https://doi.org/10.1093/clinchem/hvad061

Polygenic Risk Scores: Genomes to Risk Prediction

Moderator: Tristan J. Hayeck
Experts: George B. Busby, Sung Chun, Anna C.F. Lewis, Megan C. Roberts, Bjarni J. Vilhjálmsson
DOI: https://doi.org/10.1093/clinchem/hvad049

Lab Medicine in Space

Moderators: Joesph R. Wiencek, Saswati Das
Experts: Afshin Beheshti, Brian E. Crucian, Fathi Karouia, Guy Trudel, Kathleen A. McMonigal
DOI: https://doi.org/10.1093/clinchem/hvad035

Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?

Moderators: Steven W. Cotten, Frederick G. Strathmann
Experts: Frederick S. Barrett, Laura Labay, James Mullally, Alexander M. Sherwood, Frank Wiegand
DOI: https://doi.org/10.1093/clinchem/hvad016

A Spotlight on Disruptors and Innovators

Moderators: Khushbu Patel, Susan Evans
Experts: Jong Lee, Vamsee Pamula, Ajay Shah, Timothy E. Sweeney, Amogha Tadimety
DOI: https://doi.org/10.1093/clinchem/hvad004

Laboratory Preparedness for the Current Monkeypox Outbreak

Moderator: Kyle G. Rodino
Experts: N. Esther Babady, Gonzalo Bearman, Matthew J. Binnicker, Stuart N. Isaacs, Benjamin A. Pinsky, David J. Weber
DOI: https://doi.org/10.1093/clinchem/hvac198

One Bad Apple Can Spoil the Bunch: The Impact of Contamination in the Clinical Laboratory

Moderators: Hannah Marie Brown, Christopher W. Farnsworth
Experts: Andrew Bryan, Jonathan R. Genzen, Ann Gronowski, Jamie Philips Deeter, Melanie Yarbrough
DOI: https://doi.org/10.1093/clinchem/hvac182

2022

Rising to the Challenge: Shortages in Laboratory Medicine

Moderator: Claire E. Knezevic
Experts: Barnali Das, Joe M. El-Khoury, Paul J. Jannetto, Felicitas Lacbawan, William E. Winter
DOI: https://doi.org/10.1093/clinchem/hvac179

Clinical Laboratory Informatics and Analytics: Challenges and Opportunities

Moderator: Sarah E. Wheeler
Experts: Darci R. Block, Dustin R. Bunch, Jamie Gramz, Edward Ki Yun Leung, David S. McClintock, J. Mark Tuthill
DOI: https://doi.org/10.1093/clinchem/hvac157

Differences between Educational and Regulatory External Quality Assurance/Proficiency Testing Schemes

Moderator: Tony Badrick
Experts: Graham Jones, W. Greg Miller, Mauro Panteghini, Andrew Quintenz, Sverre Sandberg, Michael Spannagl
DOI: https://doi.org/10.1093/clinchem/hvac132

Direct-to-Consumer Testing for Routine Purposes

Moderators: Michelle Stoffel, Dina N. Greene
Experts: Stacy G. Beal, Peter Foley, Anthony A. Killeen, Hedyeh Shafi, Enrique Terrazas
DOI: https://doi.org/10.1093/clinchem/hvac106

Public Misinformation and Science Communication in Times of Public Health Crises

Moderators: Michael A. Vera, Joe M. El-Khoury
Experts: Holden Thorp, Richard J. Tofel, Joseph S. Ross, Apoorva Mandavilli, Eric Topol
DOI: https://doi.org/10.1093/clinchem/hvac088

Critical Roles of Clinical Laboratorians in Translational Research and Applied Sciences—Experts’ Insights and Experiences

Moderators: Christopher Farnsworth, Zhen Zhao
Experts: Fred Apple, Paul Collinson, Mari L. DeMarco, Ann Gronowski, David B. Sacks, Yusheng Zhu
DOI: https://doi.org/10.1093/clinchem/hvac074

Women in Laboratory Medicine: A Q&A on Diversity and Inclusion

Moderator: Nadia Ayala-Lopez
Experts: Octavia M. Peck Palmer, M. Laura Parnas, Lakshmi V. Ramanathan, Zahra Shajani-Yi
DOI: https://doi.org/10.1093/clinchem/hvac068

A Paradigm Shift: Engagement of Clinical Chemistry and Laboratory Medicine Trainees by Innovative Teaching Methods

Moderators: Joesph R. Wiencek, Allison B. Chambliss
Experts: Roger L. Bertholf, Steven W. Cotten, Christina Ellervik, Justin D. Kreuter, Kamran M. Mirza, Zahra Shajani-Yi
DOI: https://doi.org/10.1093/clinchem/hvac036

Interpreting EQA—Understanding Why Commutability of Materials Matters

Moderator: Tony Badrick
Experts: W. Greg Miller, Mauro Panteghini, Vincent Delatour, Heidi Berghall, Finlay MacKenzie, Graham Jones
DOI: https://doi.org/10.1093/clinchem/hvac002

Pregnancy in the Time of COVID-19: What Are the Challenges for Maternity Care?

Moderator: Lisa Hui
Experts: Marian Knight, Andrea Edlow, Caroline Homer, Margie Danchin
DOI: https://doi.org/10.1093/clinchem/hvab266

Alternative Sample Matrices Supporting Remote Sample Collection during the Pandemic and Beyond

Moderators: Emily L. Gill, Khushbu Patel
Experts: Jane A. Dickerson, Matthew C. Dulik, Russell P. Grant, Denise L. Heaney, James W. Rudge
DOI: https://doi.org/10.1093/clinchem/hvab257

At-Home Testing for Infectious Diseases: The Laboratory Where You Live

Moderators: Sophonie Jean, Carey-Ann D. Burnham
Experts: Kimberle Chapin, Omai B. Garner, Nitika Pant Pai, George Turabelidze, Susan Butler-Wu
DOI: https://doi.org/10.1093/clinchem/hvab198

2021

Molecular Approaches to Transplant Monitoring; Is the Horizon Here?

Moderator: Sean Agbor-Enoh
Experts: Michael Oellerich, Angela Wu, Philip F. Halloran, Iwijn De Vlaminck, Michael Keller
DOI: https://doi.org/10.1093/clinchem/hvab183

Perspectives on Identifying and Treating Familial Hypercholesterolemia in Childhood

Moderators: Sarah D. de Ferranti, Dhruv S. Kazi
Experts: Kirsten Bibbins-Domingo, Stephen Daniels, Barbara Howaniec, Amit V. Khera, Thomas B. Newman, Louis Vernacchio
DOI: https://doi.org/10.1093/clinchem/hvab157

Data Mining Approaches to Reference Interval Studies

Moderators: Amrom E. Obstfeld, Khushbu Patel
Experts: James C. Boyd, Julia Drees, Daniel T. Holmes, John P.A. Ioannidis, Arjun K. Manrai
DOI: https://doi.org/10.1093/clinchem/hvab137

Current Utility and Reliability of Biological Variability

Moderators: Khushbu Patel, Joe M El-Khoury
Experts: Aasne K Aarsand, Tony Badrick, Graham R D Jones, Ken Sikaris, M Laura Parnas
DOI: https://doi.org/10.1093/clinchem/hvab055

Current Testing Strategies for SARS-CoV-2 in the United States

Moderators: Mark A Cervinski, M Laura Parnas
Experts: Barton P Buxton, Justin Choi, Omai Garner, Sean X Neath, Jennifer L Zreloff
DOI: https://doi.org/10.1093/clinchem/hvab046

Evolution of Blood Sample Transportation and Monitoring Technologies

Moderators: Khushbu Patel, Joe M El-Khoury
Experts: Ana-Maria Simundic, Christopher W Farnsworth, Franziska Broell, Jonathan R Genzen, Timothy K Amukele
DOI: https://doi.org/10.1093/clinchem/hvab001

Centralized vs Decentralized Molecular Infectious Disease Testing

Moderator: Sheldon Campbell
Experts: Neil Anderson, Esther Babady, Thomas J S Durant, Ann Fisher, Norman Moore
DOI: https://doi.org/10.1093/clinchem/hvaa318

Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations

Moderators: Joe M El-Khoury, Anais A Ovalle, Mark A Cervinski
Experts: Andrew S Levey, Graham Jones, Nwamaka D Eneanya, John C Lieske, Vivekanand Jha
DOI: https://doi.org/10.1093/clinchem/hvaa333

Should LC-MS/MS Be the Reference Measurement Procedure to Determine Protein Concentrations in Human Samples?

Moderator: Andrew N Hoofnagle
Experts: Christa M Cobbaert, Vincent Delatour, Neil L Kelleher, Mark S Lowenthal,Christopher M Shuford
DOI: https://doi.org/10.1093/clinchem/hvaa256

How Can Routine Clinical Laboratories Keep Up with the Opioid Crisis?

Moderator: Christine L H Snozek
Experts: Leland B Baskin, Jessica M Boyd, Brian N Kelly, Matthew D Krasowski, S M Hossein Sadrzadeh, Danyel H Tacker
DOI: https://doi.org/10.1093/clinchem/hvaa305

The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective

Moderator: Linnea M Baudhuin
Experts: Julie De Backer, Jodie Ingles, Dianna M Milewicz, Anne Tybjaerg-Hansen
DOI: https://doi.org/10.1093/clinchem/hvaa251

2020

Cell-Free DNA Fragmentomics: The New "Omics" on the Block

Moderator: Rossa W.K. Chiu
Experts: Ellen Heitzer, Y M Dennis Lo, Florent Mouliere, Dana W Y Tsui
DOI: https://doi.org/10.1093/clinchem/hvaa258

Examining Laboratory Medicine's Role in Eliminating Health Disparities

Moderator: Sarah E. Wheeler
Experts: Octavia M Peck Palmer, Dina N Greene, Jason Y Park, Gabrielle Winston-McPherson, Timothy K Amukele, Eliseo J Pérez-Stable
DOI: https://doi.org/10.1093/clinchem/hvaa174

Patient-Based Real Time QC

Moderator: Tony Badrick
Experts: Andreas Bietenbeck, Alex Katayev, Huub H van Rossum, Mark A Cervinski, Tze Ping Loh on behalf of the International Federation of Clinical Chemistry and Laboratory Medicine Committee on Analytical Quality
DOI: https://doi.org/10.1093/clinchem/hvaa149

Challenges of High-Resolution Mass Spectrometry For Detecting Designer Drugs

Moderator: Frederick G. Strathmann
Experts: Kara L. Lynch, Alex Krotulski, Pierre Negri, Julie Cichelli, Markus R. Meyer
DOI: https://doi.org/10.1093/clinchem/hvaa118

What is Extrachromosomal Circular DNA and What Does It Do?

Moderator: Rossa W.K. Chiu
Experts: Anindya Dutta, Anton G. Henssen, Y.M. Dennis Lo, Paul Mischel, Birgitte Regenberg
DOI: https://doi.org/10.1093/clinchem/hvaa096

The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception

Moderators: Ping Wang, Neil Anderson
Experts: Yang Pan, Leo Poon, Carmen Charlton, Nathan Zelyas, David Persing, Daniel Rhoads, Hilary Babcock
DOI: https://doi.org/10.1093/clinchem/hvaa080

Fecal Microbiota Transplantations: Where Are We, Where Are We Going, And What is the Role of the Clinical Laboratory?

Moderators: Eric M. Ransom, Carey-Ann Burnham
Experts: Lee Jones, Colleen S. Kraft, L. Clifford McDonald, Andrew R. Reinink, Vincent B. Young
DOI: https://doi.org/10.1093/clinchem/hvaa021

Development, Validation, and Regulatory Considerations for a Liquid Biopsy Test

Moderators: Dana W.Y. Tsui, Gideon M. Bluementhal, Reena Philip
Experts: J. Carl Barrett, Clara Montagut, Kelli Bramlett, Marc Ladanyi, Soma Ghosh
DOI: 10.1373/clinchem.2019.305169

Use of Biomarkers to Detect and Manage Acute Kidney Injury: Has Progress Stalled?

Moderator: John C. Lieske
Experts: Kianoush Kashani, John Kellum, Jay Koyner, Ravindra Mehta, Chirag R. Parikh
DOI: https://doi.org/10.1093/clinchem/hvz026

Predictive and Precision Medicine with Genomic Data

Moderator: Linnea M. Baudhuin
Experts: Leslie G. Biesecker, Wylie Burke, Eric D. Green, Robert C. Green
DOI: 10.1373/clinchem.2019.304345

2019

Perspectives on the Changing Landscape of Measuring Cardiovascular Risk Related to LDL

Moderators: Joe M. El-Khoury, Alan T. Remaley
Experts: Børge G. Nordestgaard, Harvey W. Kaufman, Samia Mora, Jing Cao, Jeffrey W. Meeusen
DOI: 10.1373/clinchem.2019.307306

Machine Learning for Clinical Chemists

Moderator: Tony Badrick
Experts: Giuseppe Banfi, Andreas Bietenbeck, Mark A. Cervinski, Tze Ping Loh, Ken Sikaris
DOI: 10.1373/clinchem.2019.307512

Challenges Facing Society Journals

Moderator: Thomas Annesley
Experts: Kent Anderson, Angela Cochran, David Crotty, Richard Gallagher, Lisa Janicke Hinchliffe
DOI: 10.1373/clinchem.2019.310268

Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan

Moderator: Fred S. Apple
Experts: Lori B. Daniels, James Januzzi, Torbjørn Omland, Jordi Ordonez-Llanos, Allan Jaffe
DOI: 10.1373/clinchem.2018.28937

Optimal Use of Biomarkers for Chronic Kidney Disease

Moderator: W.Greg Miller
Experts: Lorin M. Bachmann, Joris R. Delanghe, Lesley A. Inker, Graham R.D. Jones, Joseph A. Vassalotti
DOI: 10.1373/clinchem.2018.299073

Biobanking for Metabolomics and Lipidomics in Precision Medicine

Moderator: Jennifer A. Kirwan
Experts: Rima Kaddurah-Daouk, Todd Mitchell, Tobias Pischon, Michael A. Schmidt, Vidya Velagapudi
DOI: 10.1373/clinchem.2018.298620

What the Protecting Access to Medicare Act Means for Clinical Laboratories

Moderators: James H. Nichols, Vincent G. Stine
Experts: Rodney W. Forsman, Lee H. Hilborne, Elissa B. Passiment, Paul Radensky, Charles B. Root, Ester Stein
DOI: 10.1373/clinchem.2019.303255

Privacy in Direct-to-Consumer Genetic Testing

Moderator: Jason Y. Park
Experts: Michael T. Risher, Timothy Caulfield, Linnea M. Baudhuin, Abraham P. Schwab
DOI: 10.1373/clinchem.2018.298935

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Moderators: Felix Leung, Livia S. Eberlin
Experts: Kristina Schwamborn, Ron M.A. Heeren, Nicholas Winograd, R. Graham Cooks
DOI: 10.1373/clinchem.2018.289694

Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome

Moderator: Joseph R. Wiencek
Experts: Christopher R. McCartney, Alice Y. Chang, Joely A. Straseski, Richard J. Auchus, Alison Woodworth
DOI: 10.1373/clinchem.2017.284331

Maintaining Research and Publication Integrity

Moderators: Nader Rifai, Thomas M. Annesley
Experts: Scott Moore, Arthur L. Caplan, Deborah J. Sweet, Peter Hornung, Frits R. Rosendaal
DOI: 10.1373/clinchem.2018.298901

The Microbiome and Men's Health

Moderator: Elizabeth A. Platz
Experts: Cindy M. Liu, Dominique S. Michaud, Noel T. Mueller, Jacques Ravel
DOI: 10.1373/clinchem.2018.287284

2018

Updates on Screening, Prevention, Treatment, and Genetic Markers for Preeclampsia

Moderator: Glenn E. Palomaki
Experts: James N. Martin, S. Ananth Karumanchi, Liona C. Poon
DOI: 10.1373/clinchem.2018.289801

Influence of Molecular Testing on Influenza Diagnosis

Moderators: Melanie L. Yarbrough, Carey-Ann D. Burnham
Experts: Neil W. Anderson, Ritu Banerjee, Christine C. Ginocchio, Kimberly E. Hanson, Timothy M. Uyeki
DOI: 10.1373/clinchem.2018.289363

Learning in the 21st Century: Concepts and Tools

Moderator: Nader Rifai
Experts: Todd Rose, Graham T. McMahon, Bror Saxberg, Ulrik Juul Christensen
DOI: 10.1373/clinchem.2018.292383

The Power of Social Media in Medicine and Medical Education: Opportunities, Risks, and Rewards

Moderator: Amy K. Saenger
Experts: Michael Berkwits, Simon Carley, Shannon Haymond, Marie Ennis-O'Connor, Jonathan Sherbino, Stephen W. Smith
DOI: 10.1373/clinchem.2018.288225

There's No Place Like Home: Exploring Home-Based, Acute-Level Healthcare

Moderators: Michelle L. Parker, Paul M. Yip
Experts: Linda V. DeCherrie, Christian Escobar, Anna K. Fuezery, Christopher P. Price, Andrew St. John
DOI: 10.1373/clinchem.2017.283093

What's New in Laboratory Test Utilization Management?

Moderator: Geoffrey S. Baird
Experts: Brian R. Jackson, Jane Dickerson, Ken Sikaris, Bernard Croal, Michael Laposata
DOI: 10.1373/clinchem.2017.280214

Current and Emerging Multianalyte Assays with Algorithmic Analyses—Are Laboratories Ready for Clinical Adoption?

Moderators: Jessica M. Colón-Franco, Patrick M.M. Bossuyt
Experts: Alicia Algeciras-Schimnich, Christopher Bird, Julia Engstrom-Melnyk, Martin Fleisher, Michael Kattan, Geralyn Lambert-Messerlian
DOI: 10.1373/clinchem.2017.275677

Debates in Pain Management Testing

Moderator: Stacy E.F. Melanson
Experts: William A. Clarke, Keith Fragoza, Christopher Gilligan, Rebecca Holdren, Paul J. Jannetto, Barbarajean Magnani, Christine Moore
DOI: 10.1373/clinchem.2017.275693

A Q&A with the Qualcomm Tricorder XPRIZE Winners

Moderators: Ann M. Gronowski, Shannon Haymond
Experts: Basil Harris, Chung Kang Peng, Sandeep (Sonny) S. Kohli
DOI: 10.1373/clinchem.2017.278853

Gestational Diabetes Mellitus: Why the Controversy?

Moderator: David B. Sacks
Experts: Donald R. Coustan, Tim Cundy, Lois Donovan, Moshe Hod
DOI: 10.1373/clinchem.2016.266577

Challenges and Opportunities in Implementing Total Laboratory Automation

Moderator: Jonathan R. Genzen
Experts: Carey-Ann D. Burnham, Robin A. Felder, Charles D. Hawker, Giuseppe Lippi, Octavia M. Peck Palmer
DOI: 10.1373/clinchem.2017.274068

Dietary Fat: Friend or Foe?

Moderators: Cara B. Ebbeling, Ian S. Young
Experts: Alice H. Lichtenstein, David S. Ludwig, Michelle McKinley, Rafael Perez-Escamilla, Eric Rimm
DOI: 10.1373/clinchem.2017.274084

2017

New Therapies for Treating Hepatitis C Virus: Impact on Laboratory Testing Recommendations and Clinical Management

Moderators: Nicole V. Tolan, Gary L. Horowitz
Experts: Joel Dore, Francisco Guarner, Ruth Ann Luna, Yehuda Ringel
DOI: 10.1373/clinchem.2016.266569

Microbiome-Based Diagnostics: Ready for Applications in Laboratory Medicine?

Moderator: James Versalovic
Experts: Camilla S. Graham, David Hillyard, William Osburn, Stuart Ray
DOI: 10.1373/clinchem.2016.264473

Impact of Novel Psychoactive Substances on Clinical and Forensic Toxicology and Global Public Health

Moderator: Marilyn A. Huestis
Simon D. Brandt, Suman Rana, Volker Auwärter, Michael H. Baumann
DOI: 10.1373/clinchem.2017.274662

The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges

Moderators: Angela W.S. Fung, Daniel Beriault, Eleftherios P. Diamandis
Experts: Carey-Ann D. Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J. Langford
DOI: 10.1373/clinchem.2017.272294

Patient Privacy and Clinical Laboratory Data

Moderator: Jason Y. Park
Experts: Toby C. Cornish, Michael Hogarth, Brian R. Jackson, Kristen B. Rosati
DOI: 10.1373/clinchem.2016.266551

The Phoenix Rises: The Rebirth of Cancer Immunotherapy

Moderators: Ivan M. Blasutig, Sofia Farkona
Experts: Elizabeth I. Buchbinder, Jason J. Luke, Padmanee Sharma, Mario Sznol
DOI: 10.1373/clinchem.2016.267849

Wellness Initiatives: Benefits and Limitations

Moderators: Michelle Li, Eleftherios P. Diamandis
Experts: Nigel Paneth, Kiang-Teck J. Yeo, Henrik Vogt, Stephen R. Master
DOI: 10.1373/clinchem.2017.273672

Emerging Considerations for Noninvasive Prenatal Testing

Moderators: Nichole Korpi-Steiner, Rossa W.K. Chiu
Experts: Subhashini Chandrasekharan, Lyn S. Chitty, Mark I. Evans, Judith A. Jackson, Glenn E. Palomaki
DOI: 10.1373/clinchem.2016.266544

Are We There Yet? Laboratory Preparedness for Emerging Infectious Diseases

Moderators: Carey-Ann D. Burnham, Jennie H. Kwon
Experts: Eileen M. Burd, Sheldon Campbell, Peter C. Iwen, Melissa B. Miller
DOI: 10.1373/clinchem.2016.265850

Direct-to-Consumer Testing

Moderators: Michelle Li, Eleftherios P. Diamandis
Experts: David Grenache, Michael J. Joyner, Daniel T. Holmes, Rodger Seccombe
DOI: 10.1373/clinchem.2016.260349

Biomedical Journals and Preprint Services: Friends or Foes?

Moderators: Thomas Annesley, Mitchell Scott
Experts: Hilda Bastian, Vivian Fonseca, John P.A. Ioannidis, Michael A. Keller, Jessica Polka
DOI: 10.1373/clinchem.2016.268227

Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury

Moderator: Fred S. Apple
Experts: Allan S. Jaffe, Scott Sharkey, Peter Kavsak, Michael C. Kontos, Amy K. Saenger, Stephen Smith
DOI: 10.1373/clinchem.2016.257428

2016

The Use of Targeted Therapies for Precision Medicine in Oncology

Moderators: Nicole White-Al Habeeb, Vathany Kulasingam, and Eleftherios P. Diamandis
Experts: George M. Yousef, Gregory J. Tsongalis, Louis Vermeulen, Ziqiang Zhu, and Suzanne Kamel-Reid
DOI: 10.1373/clinchem.2015.247882

Newborn Screening for Lysosomal Storage Disorders: Quo Vadis?

Moderators: Roy W.A. Peake and Deborah L. Marsden
Experts: Olaf A. Bodamer, Michael H. Gelb, David S. Millington and Frits Wijburg
DOI: 10.1373/clinchem.2016.258459

CRISPR-Cas9 System: Opportunities and Concerns

Moderators: Stella Vasiliou and Eleftherios P Diamandis
Experts: George Church, Henry T Greely, Françoise Baylis, Charis Thompson, and Gerold Schmitt‐Ulms
DOI: 10.1373/clinchem.2016.263186

Zika Virus: From Obscurity to Potentially Devastating International Threat

Moderators: Marie Louise Landry
Experts: Albert I. Ko, Laura D. Kramer and Nikolaos Vasilakis
DOI: 10.1373/clinchem.2016.261917

Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

Moderators: Felix Leung, Vathany Kulasingam, and Eleftherios P. Diamandis
Experts: Dave S. B. Hoon, Kenneth Kinzler, Klaus Pantel, and Catherine Alix- Panabières
DOI: 10.1373/clinchem.2016.260331

Reference Intervals: Strengths, Weaknesses, and Challenges

Moderators: W. Greg Miller and Gary L. Horowitz
Experts: Ferruccio Ceriotti, James K. Fleming, Neil Greenberg, Alexander Katayev, Graham R.D. Jones, William Rosner, and Ian S. Young
DOI: 10.1373/clinchem.2016.256511

Classifying Germline Sequence Variants in the Era of Next-Generation Sequencing

Moderators: Linnea M. Baudhuin and Birgit H. Funke
Experts: Lora H. Bean, Joshua L. Deignan, Sean Hofherr, David T. Miller, Narasimhan Nagan, Avni Santani, and Carol Saunders
DOI: 10.1373/clinchem.2015.247874

Pharmacists in the Laboratory Space: Friends or Foes?

Moderator: Ann M. Gronowski
Experts: Alex Adams, Christopher Ball, Charlotte A. Gaydos, and Michael Klepser
DOI: 10.1373/clinchem.2015.247445

Proteogenomics: Opportunities and Caveats

Moderators: Lampros Dimitrakopoulos, Ioannis Prassas, and Eleftherios P. Diamandis
Experts: Alexey Nesvizhskii, Thomas Kislinger, Jacob Jaffe, and Andrei Drabovich
DOI: 10.1373/clinchem.2015.247858

Nonfasting Sample for the Determination of Routine Lipid Profile: Is It an Idea Whose Time Has Come?

Moderators: Nader Rifai and Ian S. Young
Experts: Børge G. Nordestgaard, Anthony S. Wierzbicki, Hubert Vesper, Samia Mora, Neil J. Stone, Jacques Genest, and Greg Miller
DOI: 10.1373/clinchem.2015.247866

Clostridium difficile—Diagnostic and Clinical Challenges

Moderator: Carey-Ann D. Burnham
Experts: Erik R. Dubberke, Larry K. Kociolek, Christopher R. Polage, and Thomas V. Riley
DOI: 10.1373/clinchem.2015.243717

A Spectrum of Views on Clinical Mass Spectrometry

Moderators: Thomas Annesley and Eleftherios Diamandis
Experts: Lorin Bachmann, Samir Hanash, Bradley Hart, Reza Javahery, Ravinder Singh, and Richard Smith
DOI: 10.1373/clinchem.2015.250258

2015

Vitamin D: The More We Know, the Less We Know

Moderators: Mitchell G. Scott and Ann M. Gronowski
Experts: Ian R. Reid, Michael F. Holick, Ravi Thadhani, and Karen Phinney
DOI: 10.1373/clinchem.2014.222521

Biomarkers in the Pharmaceutical Industry

Moderator: Omar F. Laterza
Experts: Andrew Plump, Jeffrey E. Ming, Susan Richards, Michael E. (Ransom) Burczynski, John A. Wagner, and Scott D. Patterson
DOI: 10.1373/clinchem.2014.225284

"Big Data" in Laboratory Medicine

Moderators: Nicole V. Tolan and M. Laura Parnas
Experts: Linnea M. Baudhuin, Mark A. Cervinski, Albert S. Chan, Daniel T. Holmes, Gary Horowitz, Eric W. Klee, Rajiv B. Kumar, and Stephen R. Master
DOI: 10.1373/clinchem.2015.248591

Triangulating Dynamic of Clinical Laboratory Testing

Moderators: Kerri Weinert, Peter Gyorda, and Nader Rifai
Experts: Susan Evans, Harvey W. Kaufman, Charles S. Eby, Edward R. Ashwood, and Norman Moore
DOI: 10.1373/clinchem.2015.248112

Clopidogrel and CYP2C19: PharmacogeneticTesting Ready for Clinical Prime Time?

Moderators: Michael J. Knauer and Eleftherios P. Diamandis
Experts: Jean-Sebastien Hulot, Richard B. Kim, and Derek Y.F. So
DOI: 10.1373/clinchem.2015.238105

Disruptive Innovation in Laboratory Medicine

Moderator: Nader Rifai
Experts: Eric Topol, Eugene Chan, Y.M. Dennis Lo, and Carl T. Wittwer
DOI: 10.1373/clinchem.2015.243667

A Renin-ssance in Primary Aldosteronism Testing: Obstacles and Opportunities for Screening, Diagnosis, and Management

Moderators: Joshua E. Raizman and Eleftherios P. Diamandis
Experts: Daniel Holmes, Michael Stowasser, Richard Auchus, and Etienne Cavalier
DOI: 10.1373/clinchem.2015.242990

Biomarkers, Assays, and Therapies for Alzheimer Disease

Moderators: Daniel R. Beriault and Eleftherios P. Diamandis
Experts: Erik Portelius, Armand Perret-Liaudet, and Stephen Salloway
DOI: 10.1373/clinchem.2015.241901

Preanalytical Considerations in the Design of Clinical Trials and Epidemiological Studies

Moderator: Mark D. Kellogg
Experts: Christina Ellervik, David Morrow, Ann Hsing, Evan Stein, and Amar A. Sethi
DOI: 10.1373/clinchem.2014.226118

Preeclampsia: An Old Disease with New Tools for Better Diagnosis and Risk Management

Moderators: Mohamed Abou El Hassan and Eleftherios P. Diamandis
Experts: S. Ananth Karumanchi, Andrew H. Shennan, and Robert N. Taylor
DOI: 10.1373/clinchem.2014.230565

The Changing Face of Laboratory Medicine: A More Service and Less Academically Oriented Profession?

Moderators: Mitchell G. Scott and Nader Rifai
Experts: Brian Smith, Michael Oellerich, Mauro Panteghini, Fred Apple, Ken Sikaris, and Ian Young
DOI: 10.1373/clinchem.2014.230300

Next Generation Sequencing in Clinical Diagnostics: Experiences of Early Adopters

Moderator: Elaine Lyon, Franklin R. Cockerill III
Richard Press, and Glenn E. Palomaki
DOI: 10.1373/clinchem.2014.222687

2014

Animal Olfactory Detection of Disease: Promises and Pitfalls

Moderators: Tracy Teodoro-Morrison, Eleftherios P. Diamandis, and Nader Rifai
Experts: Bart Jan Christiane Weetjens, Giorgio Pennazza, Nanne K. de Boer, and Marije K. Bomers
DOI: 10.1373/clinchem.2014.231282

Critical Issues in International Biobanking

Moderator: Jim Vaught
Experts: Akin Abayomi, Tim Peakman, Peter Watson, Lise Matzke, and Helen Moore
DOI: 10.1373/clinchem.2014.224469

What Is Wrong with Clinical Proteomics?

Moderators: Ashley Di Meo and Eleftherios P. Diamandis
Experts: Henry Rodriguez, Andrew N. Hoofnagle, John Ioannidis, and Mary Lopez
DOI: 10.1373/clinchem.2014.225185

Registering Diagnostic and Prognostic Trials of Tests: Is It the Right Thing to Do?

Moderators: Nader Rifai and Patrick M.M. Bossuyt
Experts: John P.A. Ioannidis, Kurtis R. Bray, Lisa M. McShane, Robert M. Golub, and Lotty Hooft
DOI: 10.1373/clinchem.2014.226100

Natriuretic Peptides in Heart Failure

Moderators: Danny C.C. Lin and Eleftherios P. Diamandis
Experts: James L. Januzzi Jr., Alan Maisel, Allan S. Jaffe, and Aldo Clerico
DOI: 10.1373/clinchem.2014.223057

Harmonization of Test Results: What Are the Challenges; How Can We Make It Better?

Moderator: W. Greg Miller
Experts: John H. Eckfeldt, Joseph Passarelli, William Rosner, and Ian S. Young
DOI: 10.1373/clinchem.2012.201186

Novel Biomarkers for Acute Myocardial Infarction: Is MicroRNA the New Kid on the Block?

Moderators: Joshua E. Raizman and Eleftherios P. Diamandis
Experts: Katey Rayner, Stephanie Dimmeler, George A. Calin, and Thomas Thum
DOI: 10.1373/clinchem.2013.215491

Interferon γ–Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons

Moderators: Nira R. Pollock and Alexander J. McAdam
Experts: Madhukar Pai, Edward A. Nardell, John Bernardo, Niaz Banaei, and Jay Mobo
DOI: 10.1373/clinchem.2012.201178

Helicobacter pylori Diagnostics and Treatment: Could a Lack of Universal Consensus Be the Best Consensus?

Moderator: Marc R. Couturier
Experts: Barry J. Marshall, Karen J. Goodman, and Francis Mégraud
DOI: 10.1373/clinchem.2012.201475

Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now?

Moderator: Brad S. Karon
Experts: Gilles Montalescot, Neil S. Harris, Søren Risom Kristensen, and Matthew Price
DOI: 10.1373/clinchem.2013.208942

Biomarkers for Acute Kidney Injury: Where Are We Today? Where Should We Go?

Moderator: John C. Lieske
Experts: Lakhmir Chawla, Kianoush Kashani, John A. Kellum, Jr., Jay L. Koyner, and Ravindra L. Mehta
DOI: 10.1373/clinchem.2012.201988

The Ethical Implications of Preimplantation Genetic Diagnosis

Moderator: Ann M. Gronowski
Experts: Richard T. Scott, Jr., Arthur L. Caplan, and Lawrence J. Nelson
DOI: 10.1373/clinchem.2013.202515

2013

Automation in the Clinical Microbiology Laboratory

Moderator: Carey-Ann D. Burnham
Experts: W. Michael Dunne, Jr., Gilbert Greub, Susan M. Novak, and Robin Patel
DOI: 10.1373/clinchem.2012.201038

Identifying Antibiotic-Resistant Bacteria in Hospitalized Patients: What Is the Role of Active-Surveillance Cultures?

Moderator: Thomas J. Sandora
Experts: Susan A. Dolan, Stephan Harbarth, Susan S. Huang, Alexander J. McAdam, and Aaron M. Milstone
DOI: 10.1373/clinchem.2012.201046

Use of MALDI-TOF for Diagnosis of Microbial Infections

Moderators: Dana Bailey and Eleftherios P. Diamandis
Experts: Gilbert Greub, Susan M. Poutanen, Jens Jørgen Christensen, and Markus Kostrzew
DOI: 10.1373/clinchem.2013.204644

Bioinformatics: What the Clinical Laboratorian Needs to Know and Prepare For

Moderator: Gregory J. Tsongalis
Experts: Elizabeth Chao, Jill M. Hagenkord, Tina Hambuch, and Jason H. Moore
DOI: 10.1373/clinchem.2012.198226

A New Era in Prenatal Diagnosis: The Use of Cell-Free Fetal DNA in Maternal Circulation for Detection of Chromosomal Aneuploidies

Moderators: Jennifer L. Shea and Eleftherios P. Diamandis
Experts: Barry Hoffman, Y.M. Dennis Lo, Jacob Canick, and Dirk van den Boom
DOI: 10.1373/clinchem.2012.201996

FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?

Moderator: Mitchell G. Scott
Experts: Edward R. Ashwood, Thomas M. Annesley, Debra G.B. Leonard, and Michael C. Burgess
DOI: 10.1373/clinchem.2013.204958

Cobalt and Chromium Measurement in Patients with Metal Hip Prostheses

Moderators: Mathew P. Estey and Eleftherios P. Diamandis
Experts: Catherine Van Der Straeten, Stephen S. Tower, Alister J. Hart, and Thomas P. Moyer
DOI: 10.1373/clinchem.2012.193037

Iron Deficiency: What Are the Future Trends in Diagnostics and Therapeutics?

Moderator: Carlo Brugnara
Experts: John Adamson, Michael Auerbach, Robert Kane, Iain Macdougall, and Alan Mast
DOI: 10.1373/clinchem.2012.182071

Communication of Scientific Information: Is It Time to Reassess?

Moderators: Nader Rifai and John Sack
Experts: Michael A. Keller, Anurag Acharya, Philip E. Bourne, Mike Rossner, and Stewart Wills
DOI: 10.1373/clinchem.2012.194738

Pheochromocytoma

Moderators: Mathew P. Estey and Eleftherios P. Diamandis
Experts: Graeme Eisenhofer, Karel Pacak, Eamonn R. Maher, William F. Young, and Ronald R. de Krijger
DOI: 10.1373/clinchem.2012.182246

MicroRNA Analysis: Is It Ready for Prime Time?

Moderator: Gregory J. Tsongalis
Experts: George Calin, Pierre Cordelier, Carlo Croce, Federico Monzon, and Anna E. Szafranska-Schwarzbach
DOI: 10.1373/clinchem.2012.185009

Pancreatic Cancer

Moderators: Caitlin C. Chrystoja and Eleftherios P. Diamandis
Experts: Randall Brand, Felix Rückert, Randy Haun, and Rafael Molina
DOI: 10.1373/clinchem.2012.196642

2012

NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: Can We Clarify the Controversy about Cholesterol Screening and Treatment in Childhood?

Moderator: Sarah D. de Ferranti
Experts: Stephen R. Daniels, Matthew Gillman, Louis Vernacchio, Jorge Plutzky, and Annette L. Baker
DOI: 10.1373/clinchem.2012.182089

Autoimmune Diseases: Early Diagnosis and New Treatment Strategies

Moderators: Danijela Konforte and Eleftherios P. Diamandis
Experts: Walther J. van Venrooij, Rik Lories, and Michael M. Ward
DOI: 10.1373/clinchem.2012.189480

Thyroid Function during Pregnancy: Who and How Should We Screen?

Moderator: Ann M. Gronowski
Experts: James Haddow, Sarah Kilpatrick, John H. Lazarus, and Roberto Negro
DOI: 10.1373/clinchem.2012.185017

Ectopic Pregnancy

Moderators: Julie L.V. Shaw and Eleftherios P. Diamandis
Experts: Andrew Horne, Kurt Barnhart, Tom Bourne, and Ioannis E. Messinis
DOI: 10.1373/clinchem.2012.184168

Antibiotic Resistance: How Serious Is the Problem, and What Can Be Done?

Moderators: Alexander J. McAdam
Experts: David C. Hooper, Alfred DeMaria, Brandi M. Limbago, Thomas F. O'Brien, and Betsy McCaughey
DOI: 10.1373/clinchem.2011.181636

Altering the Landscape for Women in Clinical Chemistry: Perspectives from Multigenerational Leaders

Moderators: Shannon Haymond and Amy K. Saenger
Experts: Helen M. Free, Jocelyn M. Hicks, Marilyn A. Huestis, Rita Horvath, and Corinne R. Fantz
DOI: 10.1373/clinchem.2011.174284

The Obesity Epidemic

Moderators: Jennifer Shea and Eleftherios P. Diamandis
Experts: Arya M. Sharma, Jean-Pierre Després, Shereen Ezzat, and Frank Greenway
DOI: 10.1373/clinchem.2011.180976

Liquid Chromatography-Tandem Mass Spectrometry or Automated Immunoassays: What Are the Future Trends in Therapeutic Drug Monitoring?

Moderators: Gunnar Brandhorst and Michael Oellerich
Experts: Gregory Maine, Paul Taylor, Gerhard Veen, and Pierre Wallemacq
DOI: 10.1373/clinchem.2011.167189

Is Leadership a Noun or Verb?

Moderator: Thomas M. Annesley
Experts: James S. Hernandez, Angie Morgan, Ora Pescovitz, and Ian Wright
DOI: 10.1373/clinchem.2011.165639

How Well Are We Training the Next Generation of Clinical Pathologists and Clinical Laboratory Directors? A Global Perspective

Moderator: Mitchell G. Scott
Experts: Brian R. Smith, Alan H.B. Wu, Ian S. Young, Mario Plebani, and Rossa W.K. Chiu
DOI: 10.1373/clinchem.2011.171199

Newborn Screening for Metabolic Disorders: How Are We Doing, and Where Are We Going?

Moderator: Michael J. Bennett
Experts: Piero Rinaldo, Bridget Wilcken, Kenneth A. Pass, Michael S. Watson, and Ronald J.A. Wanders
DOI: 10.1373/clinchem.2011.171215

The Challenges and Concerns Companies Face Pertaining to the US Food and Drug Administration 510(k) Process for Cardiac Biomarkers

Moderators: Fred S. Apple and David Morrow
Experts: Christian Zaugg, David Hickey, Michelle Zaharik, John J. Blackwood, and Kirsten Jakobsen
DOI: 10.1373/clinchem.2011.165860

2011

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

Moderator: Andrew Hoofnagle
Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
DOI: 10.1373/clinchem.2010.158311

Invest or Not to Invest ... Not Always an Easy Question to Answer

Moderator: Susan Evans
Experts: Emery Stephans, Avi Kulkarni, Aaron Geist and Quintin Lai
DOI: 10.1373/clinchem.2010.152132

Direct-to-Consumer Genetic Testing: Reliable or Risky?

Moderators: David H. Spencer and Christina Lockwood
Experts: Eric Topol, James P. Evans, Robert C. Green, Elizabeth Mansfield, and Zivana Tezak
DOI: 10.1373/clinchem.2011.167197

Circulating Cancer Cells and Their Clinical Applications

Moderator: Eleftherios P. Diamandis
Experts: Klaus Pantel, Howard I. Scher, Leon Terstappen, and Evi Lianidou
DOI: 10.1373/clinchem.2011.166678

Painting a Moving Picture: Large-Scale Proteomics Efforts and Their Potential for Changing Patient Care

Moderator: Andrew N. Hoofnagle
Experts: Ruedi Aebersold, N. Leigh Anderson, Adam Felsenfeld, and Daniel C. Liebler
DOI: 10.1373/clinchem.2010.158311

Clinical Applications for Vitamin D Assays: What Is Known and What Is Wished for

Moderator: Michael Kleerekoper
Experts: Rosemary L. Schleicher, John Eisman, Roger Bouillon, Ravinder J. Singh and Michael F. Holick
DOI: 10.1373/clinchem.2010.154997

Oral Fluid Testing: Promises and Pitfalls

Moderator: Marilyn A. Huestis
Experts: Alain Verstraete, Tai C. Kwong, Jorg Morland, Michael J. Vincent, and Raphael de la Torre
DOI: 10.1373/clinchem.2010.152124

Alzheimer Disease: Advances in Pathogenesis, Diagnosis, and Therapy

Moderators: Maria Diamandis Pasic and Eleftherios P. Diamandis
Experts: JoAnne McLaurin, David M. Holtzman, Gerold Schmitt-Ulms, and Rémi Quirion
DOI: 10.1373/clinchem.2011.161828

Individually Tailored Immunosuppression: Is There a Role for Biomarkers?

Moderators: Gunnar Brandhorst and Michael Oellerich
Experts: ;Mercè Brunet, Richard Kowalski, Alexander Vinks and Pierre Wallemacq
DOI: 10.1373/clinchem.2010.159871

The Quest for Clean Competition in Sports: Are the Testers Catching the Dopers?

Moderator: Anthony W. Butch
Experts: John A. Lombardo, Larry D. Bowers, Julie Chu and David A. Cowan
DOI: 10.1373/clinchem.2010.155002

The Use of Human Tissues in Research: What Do We Owe the Research Subjects?

Moderator: Ann M. Gronowski
Experts: Jack Moye, Jr., David S. Wendler, Arthur L. Caplan and Michael Christman
DOI: 10.1373/clinchem.2010.154989

2010

Cancer Genomes

Moderator: Eleftherios P. Diamandis
Experts: Thomas Hudson, Olli Kallioniemi, Edison T. Liu and Carlos López-Otín
DOI: 10.1373/clinchem.2010.152140

Nanotechnology: Improving Clinical Testing?

Moderators: Paolo Fortina and Larry J. Kricka
Experts: Dawn Bonnell, Amit Kulkarni, Joseph Wang, Yuri Miyahara, and David Ure
DOI: 10.1373/clinchem.2009.138750

Epigenomics-Based Diagnostics

Moderator: Eleftherios P. Diamandis
Experts: David Sidransky, Peter W. Laird, Paul Cairns and Bharati Bapat
DOI: 10.1373/clinchem.2010.148007

Direct-to-Consumer Genotyping: Are We Ready for a Brave New World?

Moderators: Mark A. Cervinski and Gregory J. Tsongalis
Experts: Lew Bender, Lawrence M. Silverman, Mary Bet Dinulos, Jim Nickel and Wayne Grody
DOI: 10.1373/clinchem.2009.138743

High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?

Moderator: Fred S. Apple
Experts: Alan Wu, Paul Collinson, Allan Jaffe and David Morrow
DOI: 10.1373/clinchem.2009.138727

KRAS Mutation Detection: A New Look at an Old Gene

Moderators: Joel A. Lefferts and Gregory J. Tsongalis
Experts: Arief A. Suriawinata, William K. Funkhouser, Marc Ladanyi, Jan A. Nowak and J. Marc Pipas
DOI: 10.1373/clinchem.2009.138735

Microtechnology in the Clinical Laboratory: Will It Solve Analytical Problems, and When Will It Make an Impact?

Moderator: Peter Wilding
Experts: Sabeth Verpoorte, M. Allen Northrup, Paul Yager, Stephen Quake and James Landers
DOI: 10.1373/clinchem.2009.138719

Prostate Cancer Screening with Prostate-Specific Antigen Testing: More Answers or More Confusion?

Moderator: Eleftherios P. Diamandis
Experts: Patrick Walsh, Klaus Jung, William Catalona and Neil Fleshner
DOI: 10.1373/clinchem.2009.140046

Detection of Biological Agents Used for Terrorism: Are We Ready?

Moderator: Mark Kellogg
Experts: Mark Hollis, Cheryl Gauthier, and Tom O'Brien
DOI: 10.1373/clinchem.2009.139493

2009

Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?

Moderator: Eleftherios P. Diamandis
Experts: Karl V. Voelkerding, Rade Drmanac, David Agus, and John McPherson
DOI: 10.1373/clinchem.2009.133389

Clinical Assays for Human Chorionic Gonadotropin: What Should We Measure and How?

Moderator: Ann M. Gronowski
Experts: Catherine Sturgeon, Ulf-Håkan Stenman, Glenn D. Braunstein, Anthony W. Butch and David A. Cowan
DOI: 10.1373/clinchem.2009.133595

Tight Glucose Control in Critically Ill Patients: Should Glucose Meters Be Used?

Moderator: David B. Sacks
Experts: Greet Van den Berghe, Sue Kirkman, Gerald Kost, Ron Ng and Sverre Sandberg
DOI: 10.1373/clinchem.2009.131318

Protein Quantification by Mass Spectrometry: Is It Ready for Prime Time?

Moderator: Eleftherios P. Diamandis
Experts: Samir Hanash, Mary Lopez, Steven Carr, and Emanuel F. Petricoin III
DOI: 10.1373/clinchem.2009.128058

Mass Spectrometry in the Clinical Laboratory: How Have We Done, and Where Do We Need to Be?

Moderator: Thomas Annesley
Experts: Joseph Majzoub, Ann Hsing, Alan Wu, Alan Rockwood and Donald Mason
DOI: 10.1373/clinchem.2009.127522