As the most trusted and authoritative journal in laboratory medicine, Clinical Chemistry strives to advance the field by showcasing vital research that holds the key to challenging patient health problems. The papers the journal publishes drive clinical testing forward and are chosen based on the novelty of their findings as well as the high quality of the scientific evidence they present.
ADLM Professional, Transitional, and Trainee members receive access to Clinical Chemistry as a free member benefit.
Confined placental mosaicism can cause false-positive prenatal cell-free DNA (cfDNA) screening results, thereby reducing the positive predictive value (PPV) of the test.
Image credit: “Cell karyotype exhibiting trisomy” by NIH Image Gallery, CC BY-NC 2.0
A recent study evaluated the diagnostic value of software-generated digital estimates of trophoblastic mosaicism to identify false-positive screenings and inform posttest counseling.
