A 40-year-old male with a history of alcohol use disorder and severe depression presented to the hospital with decompensated cirrhosis and an ongoing drug rash with mucosal involvement. One month prior, the patient was admitted to the hospital for anemia as a consequence of portal hypertensive gastropathy, acute kidney injury, and stage 3 hepatic encephalopathy. During the first days of the current hospital stay, the patient developed persistent symptomatic hypotension which was associated with a continual drop in hemoglobin and worsening coagulopathy. He was treated with intravenous fluids and blood products to correct the coagulopathy. The medications pantoprazole and ciprofloxacin, prescribed during his prior hospitalization, were discontinued due to concern about the possibility of drug reaction with eosinophilia and systemic symptoms.